Genome Size and Antibiotic Resistance

Potential impacts of aquatic pollutants: sub-clinical antibiotic concentrations induce genome changes and promote antibiotic resistance

Antibiotics are disseminated into aquatic environments via human waste streams and agricultural run-off. Here they can persist at low, but biologically relevant, concentrations. Antibiotic pollution establishes a selection gradient for resistance and may also raise the frequency of events that generate resistance: point mutations; recombination; and lateral gene transfer. This study examined th...

Antibiotics and Antibiotic Resistance

A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...

Antibiotic resistance and pyelonephritis.

Increasing antibiotic resistance threatens our ability to effectively treat bacterial infections. Antibiotic therapy enhances the growth of existing drug-resistant bacteria and the exchange of resistance mechanisms between bacteria (and even between species) and selects for resistance mutations. The effect on levels of drug-resistant infection in the population of treating 1000 people with anti...

Antibiotic Resistance

Antibiotic resistance is an ongoing evolutionary process that has been the concern of infectious disease specialists since antibiotic use gained popularity. Antibiotic resistance is not a concern of the public as reflected by their desire for antibiotics whenever illness occurs. Patients can and do pressure their physicians for antibiotics ; 12 million antibiotic prescriptions were filled for u...

antibiotic prescription and bacterial resistance